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KMID : 0370220160600060258
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Yakhak Hoeji
2016 Volume.60 No. 6 p.258 ~ p.289
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Synthesis of Phenylpyridylbutenoid Dimers and their Inhibitory activity against NO Production
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Fang Yuan-Ying
Park Hae-Il
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Abstract
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Several naturally occurring phenylbutenoid dimers were reported to possess anti-inflammatory activity. Three phenylpyridylbutenoid dimers(#1, #2 and #3) were synthesized and evaluated for their inhibitory activities against NO production from LPS-induced RAW 264.7 cells. None of the tested phenylpyridylbutenoid dimers showed any inhibitory activity against NO production, exhibiting cytotoxicity at a concentrated(100 μM) dose. These results imply that substitution of the benzene ring-A of the natural phenylbutenoid dimer(R=OMe) to a less hydrophobic pyridyl group results in loss of bioactivity.
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KEYWORD
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phenylpyridylbutenoid dimers, anti-inflammatory, nitric oxide(NO) production
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